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The muscarinic acetylcholine receptor M1, also known as the cholinergic receptor, muscarinic 1, is a muscarinic receptor. This receptor is found mediating slow EPSP at the ganglion in the postganglionic nerve, is common in exocrine glands and in the CNS. It is predominantly found bound to G proteins of class Gq that use upregulation of phospholipase C and, therefore, inositol trisphosphate and intracellular calcium as a signalling pathway. A receptor so bound would not be susceptible to CTX or PTX. However, Gi (causing a downstream decrease in cAMP) and Gs (causing an increase in cAMP) have also been shown to be involved in interactions in certain tissues, and so would be susceptible to PTX and CTX respectively. ==Effects== *EPSP in autonomic ganglia * Secretion of catecholamines from the adrenal medulla * Secretion from salivary glands * Gastric acid secretion from stomach〔 * In CNS (memory?)〔 * Vagally-induced bronchoconstriction〔 * Mediating olfactory behaviors (e.g aggression, mating) 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Muscarinic acetylcholine receptor M1」の詳細全文を読む スポンサード リンク
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